Scientific Research Division

Ming-Tao Lee (李明道), Ph. D.

Associate Research Scientist

Life Science Group

Office: Room S109, R&D Building

E-Mail: mtlee@nsrrc.org.tw, 

Tel: +886-35780281-7109

 

Education               

1988-1992 B.S. in Physics, National Central University 

1999-2004 Ph.D. in Physics, National Central University

 

Employment

2004-2005 Postdoc fellow, Department of Physics, NCU

2005-2013 Assistant Scientist, NSRRC

2009-2013 Joint Assistant Professor Department of Physics, NCU

2014-            Associate Scientist, NSRRC

2014-           Joint Associate Professor Department of Physics, NCU

 

 

Research Interest

My research interests focus on the membrane biophysics and related biology. 

(1) Protein-membrane interaction

    The structures and related functions of membrane proteins are hot topics in structure biology. The membrane proteins are able to fold to correct structures in proper membrane conditions to carry out their functions. It is my firm belief that well-controlled membrane conditions did provide more effective and correct solutions for studying the structures of membrane proteins. To understand the mechanism of protein-membrane interaction should be the key issue for study the difficult problems of membrane proteins.

 

(2) Drug-membrane interaction

    The antimicrobial peptides are the nature weapon for cell to kill the invaded bacteria and microbes by target their membrane instead of receptor. They are hopefully to avoid the drug resistance and become the new generation drug. Otherwise, a number of nature compounds, such as curcumin extracted from ginger and EGCg extracted from green tea, were known to target membrane directly to regulate the important processes in cell. The studies on these membrane-active molecules are able to be applied into drug design and human therapy.

 

(3) Bio-materials

    The proteins and enzymes are frequently used to be not only the bio-sensors but also bio-switches. They exclusively perform the correct functions in the suitable membrane structure. Thus the membrane is the most used substrate of bio-chips as well as bio-circuit. How to control and arrange membrane structure is the key issue for the important applications.

 

Highlights of our research include developing the methods of small angle X-ray scattering (SAXS), lamellar X-ray diffraction (LXD) and anomalous X-ray diffraction for membrane structures and the method of giant unilamellar vesicles (GUVs) on the interactions between bio-molecules and membranes.

 

 

 

 

 

 

 

 

Selected Publication

 

1. C.-J. Su, S.-S. Wu, U. S. Jeng*, M.-T. Lee*, A.-C. Su, K.-F. Liao, W.-Y. Lin, Y.-S. Huang and C.-Y. Chen, Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (2), 528-534 (2013).

 

2. M.-T. Lee*, T.-L. Sun, W.-C. Hung* and H. W. Huang*, Proceedings of the National Academy of Sciences 110 (35), 14243-14248 (2013).

 

3. U.-S. Jeng*, C. H. Su, C.-J. Su, K.-F. Liao, W.-T. Chuang, Y.-H. Lai, J.-W. Chang, Y.-J. Chen, Y.-S. Huang, M.-T. Lee, K.-L. Yu, J.-M. Lin, D.-G. Liu, Z.-F. Chang, C.-Y. Liu, C.-H. Chang and K. S. Liang*, J. Appl. Cryst. 43, 110-121 (2010).

 

4. Y. Sun, C.-C. Lee, W.-C. Hung, F.-Y. Chen, M.-T. Lee and H. W. Huang*, Biophys. J. 95, 2318-2324 (2008).

 

5. M.-T. Lee, W.-C. Hung, F.-Y. Chen* and H. W. Huang*, Proc. Natl. Acad. Sci. USA 105, 5087-5092 (2008).

 

6. W.-C. Hung, F.-Y. Chen, C.-C. Lee, Y. Sun, M.-T. Lee and H. W. Huang*, Biophys. J. 94, 4331-4338 (2008).

 

7. W.-C. Hung, M.-T. Lee, F.-Y. Chen and H. W. Huang*, Biophys. J. 92, 3960-3967 (2007).

 

8. Y.-H. Lai, Y.-S. Sun, U.-S. Jeng*, J.-M. Lin, T.-L. Lin, H.-S. Sheu, W.-T. Chuang, Y.-S. Huang, C.-H. Hsu, M.-T. Lee, H.-Y. Lee and K. S. Liang*, J. Appl. Cryst. 39, 871-877 (2006).

 

9. W.-C. Hung* and M.-T. Lee, Chinese J. Phys. 44, 137-149 (2006).

 

10. M.-T. Lee, W.-C. Hung, F.-Y. Chen and H. W. Huang*, Biophys. J. 89, 4006-4016 (2005).