Scientific Research Division

Chen-Lin Liu (劉振霖), Ph. D.

Assistant Research Scientist

Molecular Science Group

Office: Room S320, R&D Building

E-Mail: liu.cl@nsrrc.org.tw, 

Tel: +886-35780281-7337

Lab Webpage

Education               

2008 Ph. D. in Physical Chemistry National Tsing Hua University, Hsinchu, Taiwan

           Taiwan International Graduate Program, Taipei, Taiwan 

2001 M. S. in Chemistry National Chiao Tong University, Hsinchu, Taiwan 

1999 B. S. in Chemistry National Chiao Tong University, Hsinchu, Taiwan 

 

Employment

2010－            Assistant Research Scientist, NSRRC

2008－2010  Postdoctoral Fellow University of California, Berkeley & Lawrence Berkeley National Laboratory 

2008－2008  Postdoctoral Fellow Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan

2002－2006  Research Assistant Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan

 

Award

• Advanced Abroad Research Fellowship, 2009-2010.

• The outstanding poster prize of Annual Chinese Chemical Society & ICCT 2007 Joint Conference.

• TIGP Student Conference Travel Grant, 2007.

 

Research Interest

   We have built a set that contains matrix-assisted laser desorption / ionization (MALDI) coupled with an orthogonal acceleration time-of-flight mass spectrometer (OA-TOF-MS). Using synchrotron radiation light source with tunable soft X-ray to excite specific atom of a biological molecules, the core electron is stimulate to a particular molecular orbital followed by ionization and fragmentation simultaneously. The composition of the ionic fragments and some other features will be obtained by utilizing time-of-flight mass spectrometer. Using this method and the knowledge of element- and site-specific properties learned by other scientists, we are going to obtain the specificity of selective bond dissociation of bio-molecules (especially carbohydrates) from mass spectra. The analyzed data will be utilized to help determine the structure of important biological macromolecules such as carbohydrates through a series research of biological molecules. The short-term goal is to study the selectivity of bond breaking for small biological molecules/sugar-based molecules and to look for bio-molecular mass characteristics of selective bond breaking by comparing the mass spectra of different positions of excited oxygen atoms or carbon atoms.

 

 

 

 

Selected Publication

 

1. Chen-Lin Liu, J. D. Smith, D. L. Che, M. Ahmed, S. R. Leone, and K. R. Wilson*, “The Direct Observation of Secondary Radical Chain Chemistry in the Heterogeneous Reaction of Chlorine Atoms with Submicron Squalane Droplets”, Phys. Chem. Chem. Phys., 13, 8993 - 9007 (2011).

 

2. Yi-Shiue Lin, Kun-Ta Lu, Yuan T. Lee, Chien-Ming Tseng, Chi-Kung Ni, and Chen-Lin Liu*, “Near-Edge X-ray Absorption Fine Structure Spectra and Site-Selective Dissociation of Phenol”, J. Phys. Chem. A, 118, 1601 - 1609 (2014).

 

3. Yi-Shiue Lin, Shu-Yu Lin, Yuan T. Lee, Chien-Ming Tseng, Chi-Kung Ni, Chen-Lin Liu*, Cheng-Cheng Tsai, Jien-Lian Chen, and Wei-Ping Hu*, “Core Excitation, Specific Dissociation and the Effect of the Size of Aromatic Molecules Connected to Oxygen: Phenyl Ether and 1,3-Diphenoxybenzene”, J. Phys. Chem. A, 118, 7803 - 7815 (2014).